The Ebola virus disease (EVD) outbreak, caused by the Bundibugyo virus, continues its relentless spread across the Democratic Republic of Congo (DRC) and Uganda, prompting heightened international concern and a surge in response efforts. As of June 11, 2026, a staggering 695 confirmed cases have been reported across both nations, resulting in 138 deaths. The outbreak, declared a public health emergency of international concern by the World Health Organization (WHO) on May 17, 2026, is unfolding in a region already grappling with humanitarian crises, insecurity, and significant population movement, all of which exacerbate the challenges of containment [3, 7, 9, 10].

The Democratic Republic of Congo remains the epicenter of the epidemic, with 676 confirmed cases and 136 fatalities reported as of June 10, 2026 [3]. The Ituri Province is the most severely affected, accounting for a vast majority of the cases [4]. The outbreak has spread to North Kivu and South Kivu provinces, impacting numerous health zones, some of which are situated near refugee camps and densely populated areas [4, 6]. The DRC has experienced its 17th Ebola outbreak since the virus was first identified in 1976, with this current epidemic beginning only five months after the conclusion of the previous one [5, 11].

Uganda has confirmed 19 cases, including two deaths, as of June 11, 2026 [3]. The cases in Uganda are epidemiologically linked to transmission originating in the DRC, with evidence of both imported infections and secondary transmission among contacts and healthcare workers [3]. Notably, the three most recent cases in Uganda were reported on June 5, and no new cases have emerged since then [4]. The confirmed cases in Uganda have been concentrated in Kampala and the neighboring Wakiso district, with no documented community transmission within Uganda itself. Exposure risks are primarily associated with healthcare settings and cross-border movements, with a significant proportion of cases being Congolese nationals seeking medical care in Uganda [4, 8].

The Bundibugyo virus strain involved in this outbreak presents particular challenges, as existing Ebola treatments were primarily developed for a different strain, the Zaire ebolavirus. While research is ongoing for potential vaccines and therapeutics, none are currently approved for this specific strain [7, 11].

In response to the escalating crisis, national authorities in both the DRC and Uganda, in close collaboration with the WHO and international partners, are implementing a comprehensive suite of containment and response measures. These include bolstering surveillance, enhancing contact tracing, improving clinical management and infection prevention, and engaging communities in the response efforts [3, 7]. A joint continental Ebola response plan has been launched by the Africa Centres for Disease Control and Prevention (Africa CDC) and WHO, seeking significant funding to bolster preparedness and response capabilities across African nations [8]. Despite these efforts, the prevailing conditions of insecurity, limited infrastructure, and high population mobility continue to pose significant hurdles to effective containment [6, 11].