The United States' "America First" Global Health Strategy, aimed at shifting health aid towards bilateral agreements and increased country ownership, is encountering significant setbacks and resistance from several partner nations. Despite the administration's push to establish these new Memoranda of Understanding (MOUs) for the 2026-2030 period, concerns over data sharing, cofinancing terms, and perceived inequities are leading to rejections and stalled negotiations.

As of early June 2026, the U.S. Department of State has signed bilateral health agreements with 32 countries, totaling approximately $20.3 billion in new health funding, with the U.S. contributing $12.8 billion and partner countries committing $7.5 billion in co-investment. However, the implementation of these agreements is proving more complex than anticipated.

Several countries have voiced strong objections to the terms of the proposed agreements. Ghana, for instance, rejected its bilateral health agreement, citing unfair data-sharing provisions. Similarly, the Zambian government has opposed linking health agreements to critical mineral access and data sharing requirements, though the U.S. has continued to provide HIV treatment in the interim. Kenya faced a temporary setback when its court froze the bilateral health agreement due to data sharing concerns and cofinancing terms, although implementation planning is now complete.

These challenges highlight a growing tension between the U.S. strategy, which emphasizes transitioning programs from U.S. assistance to long-term country ownership with increased domestic spending, and the realities on the ground in many recipient nations. Concerns have also been raised about the potential for health aid to be leveraged for terms beneficial to the U.S., such as access to natural resources and sensitive health data, particularly following the dissolution of the U.S. Agency for International Development (USAID) in early 2025.

The "America First" strategy, which began in September 2025, has also seen a broader impact on global health financing. Overall global health financing dropped by 21% from 2024 to 2025, with further reductions anticipated for multilateral organizations. The U.S. and the Global Fund to Fight AIDS, Tuberculosis and Malaria, the top two global health donors, are both reducing funding to many of the same countries, creating a significant funding gap estimated to reach $4.3 billion between 2026 and 2029.

Experts have cautioned that a strategy focused primarily on national security and bilateralism risks weakening trust, eroding multilateral cooperation, and fragmenting global responses to shared health challenges. The shift away from robust support for comprehensive health systems and the potential for increased dependency on U.S. priorities due to cofinancing requirements could strain crucial health areas that previously received U.S. support.

As the U.S. navigates these challenges, the long-term impact on global health equity, the reputation of the U.S. as a reliable partner, and the ability to effectively combat future health crises remains a significant concern.